Just to post my experience, I originaly built a small sump(10gal) and used thin plexiglas, i think 1/8". I had problems with bowing and then I had problems with silicon strength when different chambers had very different quantities of water. My sump is very unique compared to all the other sumps I see(it has two chambers on one side about 4"x4" each with a bubble trap in the middle, a large middle section for sand, live rock and a mantis shrimp, and a 5"x5" section in the right corner as a pump return area).
I am currently building another sump and Im using 1/4" plexiglas and Im using much more silicon than I used the first time. I made a custom silicon 'shaper' to add a consistent shape to the edges of all my silicon and increase the thickness. This should really help. I could post pictures soon.
I hope this helps, I just don't want anyone to be in my current situation with a sump that is falling apart and has pvc pipe supports all over the place, haha, doh!