Like woodwork, Plan well, measure twice, cut once. DaveK nailed it. There are as many ways to setup a tank, as there are tanks. How best to setup the tank, depends entirely on what you want to keep in the tank. Yes, Overflows can be added without adding Overflow walls. Glass-Cages.com sells overflow Kits, complete with bulkhead and box, suitable for both glass/acrylic aquariums. A simple bulkhead with a strainer can be used as a drain, however it wont give you the Surface Skimming some type of overflow box will. Marine aquariums without surface skimming tend to develop a surface "Scum". Oily byproducts of the life cycle inside the tank. Thats why most Marine tanks have overflow boxes. When this surface scum is drained through an overflow and churned with water, it will mix, and thus can be filtered out with Skimmers, GAC/GFO reactors etc. without the surface skimming of the overflow boxes, the alternative is to use powerheads/pumps to agitate the surface and force it to mix. I've used Glass-holes.com overflow kits with a good deal of success and i recommend them. Up to you. Acrylic tanks are a bit more flexible in their configuration than glass, and are easier to change. You dont need the Diamond bit used for glass, a simple holecutter from any hardware store will work. There are other types of overflows.
Bean Animal or Herbie work well. They take some DIY to construct, but once done they are unmatched in their performance. For a tank that size, you'll want a good height to the stand so you can fit a good size sump under it. The sump gives more volume for stability, and allows you to hide Heaters, Filters, Skimmers, Reactors, and refugiums, and control the amount of flow through these so as to maximize performance. If you are looking for someone to tell you, "THIS is how you need to set it up", im afraid you wont get a strait answer. Its not that we are deliberatly trying to avoid answering, its that there's too many variables and too many Right Answers.
How experienced with Marine aquariums are you? If you havent had a tank that large before, there are a few things to consider.
A tank that size comes with its own challenges. If you intend to keep coral, you wont be able to find a "single fixture" that will cover the whole tank. You will have to get multiple smaller units and either construct a frame to hold them, or a hood to hide them. Coral quality lights are not cheap. The depth of the tank and the type of coral u want to keep are variables to deciding lights. if its under 24" Deep, T5ho will work with 6-8 bulbs. If its over 24" Deep, Metal halides or LED's may be your only choice.
Filtration. A single skimmer that can handle a tank that large wont be cheap, nor small. You may depending on space restrictions and sump size, decide to go with 2 or 3 smaller units, but again its up to you.
Fish only tanks - no special lights req, but filtration will be a challenge
Fish only with live rock - (FOWLR) req no special lights, and filtration is primarily handled by the rock, but skimmers will be needed.
Reef - Coral ready lighting is manditory, but how much depends on what you want to keep. Soft corals are the least demanding, LPS is middle, and SPS is the highest demanding coral.
When you decide what type of tank you want, if coral what kinds, etc. we can help more. This isnt FW. There's no one absolute right way to do it.