I have a pressure gage on my inlet to my RO/DI prefilters, 70psi, and another one after the third prefiter outlet/inlet to the RO membrane, when filters are new I have a 4psi difference, when the sediment filter is looking dirty, and I get to a 8psi differential, I change the 3 prefilters. I make 60 RO/DI every 3-4 weeks. My water is from a 3 deep well municipality water system, and the water is treated, runs about 580TDS, I have a Filmtec 75gpd, TDS's out run about 8, then thru 2 DI vertical, standard size canisters. I get about 160g from the first DI canister changed at 1TDS with an inline meter, then flip the second one to the first position and refill the other one and use that as the second one. I hope this helps!!!