As far as drilling, you first have to make sure that the glass sections you decide to drill the holes into is not made of tempered glass. Tempered glass will shatter as soon as you start drilling. Some aquairums come with this type of glass on the bottom. So try your best to identify this if at all possible.
Some of my local fish stores (LFS) drill the holes for you for about $20 a hole. Or, maybe some local glass cutting stores could do this for you also.
As far as how many, for a 150, I would have to recommend a total of four holes. Two drains and two returns. One of each should be as far apart as possbile. For example, one drain and one return near the back glass and close to the side glass of each side.
Something else to consider before drilling...be sure you know exactly how big of a hole you want. For example, of you want a 1" hole, then you need to drill a 1 3/4 inch hole to accomodate the bulkhead that has a 1" opening. Also make sure that the hole is drilled far enough from the glass on the back, side, and or adjacent hole to allow the bulkhead to fit properly.
Good Luck;
